Open-source scientific software from our lab, built to be used, audited, and extended by other researchers.
Multi-Scale Entropy Profiling integrates per-cell Shannon entropy with across-cells coefficient of variation (CV), decomposed by biological pathway, to characterise population-level transcriptomic coordination in single-cell RNA-seq data. The framework reveals states invisible to single-scale analyses — such as populations that are individually diverse (high per-cell entropy) yet collectively disciplined (low across-cells CV) — and is applicable to any cancer type or cellular system.
pip install msep
VUS Lens is a deterministic ACMG classification engine that does something most variant interpretation tools do not: it audits whether the evidence behind a call is actually strong enough for the patient's ancestry, rather than assuming Western-centric reference databases generalize across populations. Its reasoning layer is built with Claude.
VUS Pipeline is a production-grade clinical decision-support system that applies the ACMG/AMP 2015 + ClinGen SVI + Tavtigian point framework deterministically, gathers evidence in parallel from authoritative sources, and layers advisory mechanistic interpretation on top — every step traceable and source-cited. The class is set by rules, never by an LLM.